Long non-coding RNA regulates bone metabolism via Wnt/β-catenin signaling pathway / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 2342-2350, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-887801
ABSTRACT
The balance of bone metabolism depends on the dynamic balance between bone formation and bone resorption. Wnt/β-catenin signaling pathway is involved in the regulation of bone resorption and bone formation, and plays an important role in maintaining the balance of bone metabolism. Recently, long non-coding RNA (lncRNA) is shown to play an essential role in different process of bone metabolism. LncRNA can also regulate the balance of bone metabolism via Wnt/β-catenin signaling pathway. Few studies report that lncRNA regulates bone metabolism via Wnt/β-catenin signaling pathway. Therefore, we summarize here the role of lncRNA in bone metabolism from the perspective of Wnt/β-catenin signaling pathway. LncRNA indirectly regulates Wnt/β-catenin signaling pathway by targeting miRNAs as well as activating or inhibiting Wnt/β-catenin signaling pathway via targeting the key molecules of Wnt/β-catenin signaling pathway, thus to regulate bone metabolism. These findings provide new ideas and directions for the study of the mechanism whereby lncRNA regulates bone metabolism.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
MicroRNAs
/
Cell Line, Tumor
/
Cell Proliferation
/
Wnt Signaling Pathway
/
RNA, Long Noncoding
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2021
Type:
Article
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