Immunization against porcine epidemic diarrhea virus and vaccine development / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 2603-2613, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-887826
ABSTRACT
Porcine epidemic diarrhea (PED) is a major disease of pigs that inflicts heavy losses on the global pig industry. The etiologic agent is the porcine epidemic diarrhea virus (PEDV), which is assigned to the genus Alphacoronavirus in the family Coronaviridae. This review consists of five parts, the first of which provides a brief introduction to PEDV and its epidemiology. Part two outlines the passive immunity in new born piglets and the important role of colostrum, while the third part summarizes the characteristics of the immune systems of pregnant sows, discusses the concept of the "gut-mammary gland-secretory IgA(sIgA) axis" and the possible underpinning mechanisms, and proposes issues to be addressed when designing a PEDV live vaccine. The final two parts summarizes the advances in the R&D of PEDV vaccines and prospects future perspectives on prevention and control of PEDV, respectively.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Swine
/
Swine Diseases
/
Viral Vaccines
/
Immunization
/
Coronavirus Infections
/
Porcine epidemic diarrhea virus
/
Antibodies, Viral
Limits:
Animals
/
Pregnancy
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2021
Type:
Article
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