Advances of phage receptor binding proteins / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 2614-2622, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-887827
ABSTRACT
Bacteriophages bind to the bacteria receptor through the receptor binding proteins (RBPs), a process that requires the involvement of complex atomic structures and conformational changes. In response to bacteriophage infection, bacteria have developed a variety of resistance mechanisms, while bacteriophages have also evolved multiple antagonistic mechanisms to escape host resistance. The exploration of the "adsorption-anti adsorption-escape process" between bacteriophages and bacteria helps us better understand the co-evolution process of bacteriophages and bacteria, which is important for the development of phage therapeutic technologies and phage-based biotechnologies. This review summarizes the bacteriophage adsorption related proteins, how bacteriophages escape host resistance based on the RBP alternations, and the recent progress of RBP-related biotechnologies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Protein Binding
/
Bacteria
/
Bacteriophages
/
Carrier Proteins
/
Bacteriophage Receptors
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2021
Type:
Article
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