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Roles of Myeloid-derived Suppressor Cells in Breast Cancer Metastasis / 中国医学科学院学报
Article in Zh | WPRIM | ID: wpr-887878
Responsible library: WPRO
ABSTRACT
Breast cancer patients with bone,liver and lung metastases tend to have a poor prognosis.According to Paget's "seed and soil" theory,metastatic cancer cell "seeds" must fall on congenial target organ "soil".Studies have shown that myeloid-derived suppressor cells(MDSCs)can be recruited at the site of breast cancer metastasis in advance and play a role in the metastasis of breast cancer cells.This paper reviews the biological characteristics of MDSCs,the roles of MDSCs in peripheral circulation,prometastatic niche,and metastatic site during breast cancer metastasis,as well as the research progress of MDSCs-targeted treatment of breast cancer metastasis.
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Full text: 1 Index: WPRIM Main subject: Breast Neoplasms / Tumor Microenvironment / Myeloid-Derived Suppressor Cells / Lung Neoplasms / Neoplasm Metastasis Type of study: Prognostic_studies Limits: Female / Humans Language: Zh Journal: Acta Academiae Medicinae Sinicae Year: 2021 Type: Article
Full text: 1 Index: WPRIM Main subject: Breast Neoplasms / Tumor Microenvironment / Myeloid-Derived Suppressor Cells / Lung Neoplasms / Neoplasm Metastasis Type of study: Prognostic_studies Limits: Female / Humans Language: Zh Journal: Acta Academiae Medicinae Sinicae Year: 2021 Type: Article