Research Progress of Pharmacological Intervention of Sevoflurane-induced Nerve Injury in the Developing Brain / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 462-468, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-887880
ABSTRACT
Sevoflurane is one of the most commonly used inhaled anesthetics in obstetric and pediatric general anesthesia.According to related literature,this article reviews major possible mechanisms including myelin formation damage,nerve inflammation,cell apoptosis,oxidative stress,inhibition of histone acetylation,synapsis and receptor changes of sevoflurane-induced neurotoxicity in animal experiments.Furthermore,we summarize the neuroprotection effects and functioning mechanisms of anti-anemia medicine,plant-based drugs,alpha 2 adrenoceptor agonists and others,aiming to provide a basis for the brain protection of fetuses and infants during the perioperative period.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Brain
/
Apoptosis
/
Oxidative Stress
/
Neuroprotective Agents
/
Anesthetics, Inhalation
/
Sevoflurane
/
Methyl Ethers
Limits:
Animals
/
Female
/
Humans
/
Pregnancy
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2021
Type:
Article
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