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Mechanisms and application of triptolide against breast cancer / 中国中药杂志
Article in Chinese | WPRIM | ID: wpr-887974
Responsible library: WPRO
ABSTRACT
Overtaking lung cancer,breast cancer is now the most commonly diagnosed cancer seriously threatening people's health and life. As the main effective component of Tripterygium wilfordii,triptolide( TP) has attracted increasing attention due to its multitarget and multi-pathway anti-tumor activity. Recent studies have revealed that breast cancer-sensitive TP enables the inactivation of breast cancer cells by inducing tumor cell apoptosis and autophagy,interfering in tumor cell metastasis,resisting drug resistance,arresting tumor cell cycle,and influencing tumor microenvironment. It has been recognized as a promising clinical antitumor agent by virtue of its widely accepted therapeutic efficacy. This paper reviewed the anti-breast cancer action and its molecular mechanisms of TP on the basis of the relevant literature in the past ten years,and proposed application strategies in view of the inadequacy of TP to provide a reference for further research on the application of TP in the treatment of breast cancer.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Phenanthrenes / Breast Neoplasms / Female / Humans / Diterpenes / Epoxy Compounds / Tumor Microenvironment Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phenanthrenes / Breast Neoplasms / Female / Humans / Diterpenes / Epoxy Compounds / Tumor Microenvironment Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2021 Type: Article