Research on anti-tumor natural product diosgenin / 中国中药杂志
Zhongguo Zhong Yao Za Zhi
; (24): 4360-4366, 2021.
Article
in Zh
| WPRIM
| ID: wpr-888134
Responsible library:
WPRO
ABSTRACT
Diosgenin is widely distributed in many plants, such as Polygonatum sibiricum, Paris polyphylla, Dioscorea oppositifolia, Trigonella foenum-graecum, Costus speciosus, Tacca chantrieri, which has good anti-tumor activity and preferable effects on preventing atherosclerosis, protecting the heart, treating diabetes, etc. This review combed through the anti-tumor mechanisms of diosgenin encompassing lung, breast, gallbladder, liver, oral cavity, stomach, bladder, bone marrow, etc. Besides, it was discovered that diosgenin mainly exerts its effect by inhibiting tumor cell migration, suppressing tumor cell proliferation and growth, and inducing cell apoptosis. However, problems like low yield and bioavailability frequently exist in natural diosgenin. This review introduced methods such as structural modification, dosage form optimization and combination medication to improve the yield and anti-tumor activity of diosgenin. Via the summary of this paper, it is expected to provide theoretical basis for the rational exploitation and utilization of diosgenin.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Biological Products
/
Apoptosis
/
Trigonella
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Cell Proliferation
/
Diosgenin
Language:
Zh
Journal:
Zhongguo Zhong Yao Za Zhi
Year:
2021
Type:
Article