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Research advance of pharmacological effects of astragalosides on nervous system diseases / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 4674-4682, 2021.
Article in Chinese | WPRIM | ID: wpr-888171
ABSTRACT
Astragali Radix is a traditional Chinese herbal medicine with a long history, which has the functions of tonifying Qi and promoting urination and granulation. Astragalosides are the main effective components of Astragali Radix, and more than 40 triterpenoid saponins have been obtained from Astragalus membranaceus and its related plants, mainly including astragalosides Ⅰ-Ⅷ, isoastragalosides Ⅰ, Ⅱ, and Ⅳ, acetylastragalosides, and soyasaponins. Astragalosides have a wide range of biological activities, such as immunomodulation, antioxidation, and neuroprotection. Nervous system diseases seriously affect people's quality of life, threaten human physical and mental health, and impose a burden on families and society. As natural drugs, astragalosides have good preventive and therapeutic effects on central nervous system diseases. This paper reviews the main pharmacological effects and mechanisms of astragalosides in the treatment of multiple sclerosis, Parkinson's disease, Alzheimer's disease, and cerebral ischemic stroke and proposes the research prospects and potential problems, aiming to provide reference for the clinical application and basic research of astragalosides.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Quality of Life / Saponins / Drugs, Chinese Herbal / Astragalus Plant / Astragalus propinquus / Nervous System Diseases Limits: Humans Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Quality of Life / Saponins / Drugs, Chinese Herbal / Astragalus Plant / Astragalus propinquus / Nervous System Diseases Limits: Humans Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2021 Type: Article