Research progress of necroptosis on bone related diseases / 中国骨伤
China Journal of Orthopaedics and Traumatology
;
(12): 687-690, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-888340
ABSTRACT
As a new type of cell death, necroptosis is initiated by tumor necrosis factor receptor 1(TNFR1), and then activated receptor-interacting protein kinase 1(RIP1) and receptor-interacting protein kinase 3 (RIP3), following by the activation of mixed lineage kinase domain-like protein(MLKL) to deliver cell death signal. When necroptosis happens, damage associated molecular patterns (DAMPs) enter into extracellular area through the ruptured cytomembrane, followed by the disordered tissue hemeostasis. In recent years, many researches showed that necroptosis playimportant roles in a few bone related diseases, such as osteoporosis, osteonecrosis, osteosarcoma, etc. Thus, we try to briefly review the researches in this field.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Protein Kinases
/
Apoptosis
/
Necroptosis
Language:
Chinese
Journal:
China Journal of Orthopaedics and Traumatology
Year:
2021
Type:
Article
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