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Serological and molecular studies of a rare A subgroup / 中华医学遗传学杂志
Chinese Journal of Medical Genetics ; (6): 807-808, 2021.
Article in Chinese | WPRIM | ID: wpr-888401
ABSTRACT
OBJECTIVE@#To determine the genotype of an individual suspected for Aw through DNA sequencing.@*METHODS@#Serologic testing was carried out with standard methods. Exons 6 and 7 of the ABO genes were amplified by PCR and subjected to direct sequencing or sequenced after gene cloning.@*RESULTS@#Serological testing showed that the forward typing and reverse typing were Aw and A, respectively. DNA sequencing revealed that the individual has carried an Aw allele and an O allele. Haplotype sequencing of each allele has revealed a nt543 variant (543G>C) in the Aw allele.@*CONCLUSION@#The individual was verified as a rare A subtype, which was previously unreported in mainland China.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Phenotype / ABO Blood-Group System / Exons / Alleles / Genotype Limits: Humans Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phenotype / ABO Blood-Group System / Exons / Alleles / Genotype Limits: Humans Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2021 Type: Article