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Research advances on haploidentical hematopoietic stem cell transplantation in the treatment of severe aplastic anemia in children / 中国当代儿科杂志
Article in English | WPRIM | ID: wpr-888493
Responsible library: WPRO
ABSTRACT
Haploidentical hematopoietic stem cell transplantation is a recommended alternative therapy for children with severe aplastic anemia who lack a human leukocyte antigen (HLA)-identical sibling donor and do not respond well to immunosuppressive therapy; however, due to non-identical HLA, the patients may have donor-specific anti-HLA antibody, which may lead to a relatively high incidence rate of poor graft function. Compared with HLA-identical transplantation, conditioning regimen for haploidentical transplantation still needs to be explored. This article reviews the detection and treatment of donor-specific anti-HLA antibody, the selection of conditioning regimen, and the mechanism and treatment of poor graft function in haploidentical hematopoietic stem cell transplantation.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Transplantation, Homologous / Humans / Child / Hematopoietic Stem Cell Transplantation / Transplantation Conditioning / Graft vs Host Disease / Anemia, Aplastic Language: English Journal: Chinese Journal of Contemporary Pediatrics Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Transplantation, Homologous / Humans / Child / Hematopoietic Stem Cell Transplantation / Transplantation Conditioning / Graft vs Host Disease / Anemia, Aplastic Language: English Journal: Chinese Journal of Contemporary Pediatrics Year: 2021 Type: Article