Research progress on proteasome subunits in regulating occurrence and development of hepatocellular carcinoma / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 396-402, 2021.
Article
in English
| WPRIM
| ID: wpr-888509
ABSTRACT
Proteasome is the eukaryotic organelle responsible for degradation of short-lived proteins and involved in maintaining cellular protein homeostasis. It has been reported that during the occurrence and development of hepatocellular carcinoma (HCC), the regulatory particle subunits of proteasome regulate a series of tumor-related proteins, and proliferation, survival-associated signaling molecules, including PTEN gene, P53, Bcl-2, Bcl-2 interacting mediator of cell death (Bim), cyclin-dependent kinase 4(CDK4), transforming growth factor β receptor (TGFBR), E2F1, growth factor receptor-bound protein 2 (GRB2) . Meanwhile, these subunits regulate some tumor-associated pathway protein, such as signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT), inducing their malfunction to promote the occurrence, proliferation, invasion and metastasis of HCC. The core particle subunits are more to perform the degradation of HCC-related proteins, so inhibitors targeting the core particle show a good anti-tumor effect. This review summarizes the current research progress on the regulation and mechanism of proteasome subunits in promoting the occurrence and development .
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Signal Transduction
/
Carcinoma, Hepatocellular
/
Cell Line, Tumor
/
Proteasome Endopeptidase Complex
/
Cell Proliferation
/
STAT3 Transcription Factor
/
Liver Neoplasms
Limits:
Humans
Language:
English
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2021
Type:
Article
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