LG-ESSs and HG-ESSs: underlying molecular alterations and potential therapeutic strategies / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
;
(12): 633-646, 2021.
Article
in English
| WPRIM
| ID: wpr-888691
ABSTRACT
Endometrial stromal tumors (ESTs) include endometrial stromal nodule (ESN), low-grade endometrial stromal sarcoma (LG-ESS), high-grade endometrial stromal sarcoma (HG-ESS), and undifferentiated uterine sarcoma (UUS). Since these are rare tumor types, there is an unmet clinical need for the systematic therapy of advanced LG-ESS or HG-ESS. Cytogenetic and molecular advances in ESTs have shown that multiple recurrent gene fusions are present in a large proportion of LG-ESSs, and HG-ESSs are identified by the tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon (
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
English
Journal:
Journal of Zhejiang University. Science. B
Year:
2021
Type:
Article
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