Proteins moonlighting in tumor metabolism and epigenetics / 医学前沿
Frontiers of Medicine
; (4): 383-403, 2021.
Article
in En
| WPRIM
| ID: wpr-888735
Responsible library:
WPRO
ABSTRACT
Cancer development is a complicated process controlled by the interplay of multiple signaling pathways and restrained by oxygen and nutrient accessibility in the tumor microenvironment. High plasticity in using diverse nutrients to adapt to metabolic stress is one of the hallmarks of cancer cells. To respond to nutrient stress and to meet the requirements for rapid cell proliferation, cancer cells reprogram metabolic pathways to take up more glucose and coordinate the production of energy and intermediates for biosynthesis. Such actions involve gene expression and activity regulation by the moonlighting function of oncoproteins and metabolic enzymes. The signal - moonlighting protein - metabolism axis facilitates the adaptation of tumor cells under varying environment conditions and can be therapeutically targeted for cancer treatment.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Epigenesis, Genetic
/
Energy Metabolism
/
Metabolic Networks and Pathways
/
Tumor Microenvironment
/
Neoplasms
Limits:
Humans
Language:
En
Journal:
Frontiers of Medicine
Year:
2021
Type:
Article