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Antioxidant and antiaging effect of traditional Thai rejuvenation medicines in Caenorhabditis elegans / 中西医结合学报
Journal of Integrative Medicine ; (12): 362-373, 2021.
Article in English | WPRIM | ID: wpr-888760
ABSTRACT
OBJECTIVE@#This study explored the rejuvenation mechanisms of Thai polyherbal medicines using different approaches, including in vitro methods, as well as a well-defined nematode model, Caenorhabditis elegans.@*METHODS@#THP-R-SR012 decoction was selected from 23 polyherbal medicines, based on metal-chelating and chain-breaking antioxidant capacities. The influences of this extract on the survival and some stress biomarkers of C. elegans under paraquat-induced oxidative stress were evaluated. Furthermore, lifespan analysis and levels of lipofuscin accumulation were examined in senescent nematodes. The phytochemical profile of THP-R-SR012 was analyzed.@*RESULTS@#Supplementation with THP-R-SR012 decoction significantly increased the mean lifespan and reduced the oxidative damage to C. elegans under oxidative stress conditions. Further, THP-R-SR012 supplementation slightly influenced the lifespan and the level of lipofuscin accumulation during adulthood. Antioxidant-related phytochemical constituents of THP-R-SR012 decoction were rutin, naringenin, 3,4-dihydroxybenzoic acid, gallic acid, glycyrrhizic acid, demethoxycurcumin and 18α-glycyrrhetinic acid.@*CONCLUSION@#The antioxidant potential of THP-R-SR012 was due to its scavenging properties, its enhancement of antioxidant-related enzyme activities, and the presence of the antioxidant-related compound. These results support the traditional use of THP-R-SR012 decoction as a tonic for nourishing and strengthening the whole body.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Rejuvenation / Thailand / Plant Extracts / Reactive Oxygen Species / Caenorhabditis elegans / Oxidative Stress / Caenorhabditis elegans Proteins / Antioxidants Limits: Animals Country/Region as subject: Asia Language: English Journal: Journal of Integrative Medicine Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Rejuvenation / Thailand / Plant Extracts / Reactive Oxygen Species / Caenorhabditis elegans / Oxidative Stress / Caenorhabditis elegans Proteins / Antioxidants Limits: Animals Country/Region as subject: Asia Language: English Journal: Journal of Integrative Medicine Year: 2021 Type: Article