Extensive expansion of the chemical diversity of fusidane-type antibiotics using a stochastic combinational strategy

Xiaojun SONG; Jianming LV; Zhiqin CAO; Huiyun HUANG; Guodong CHEN; Takayoshi AWAKAWA; Dan HU; Hao GAO; Ikuro ABE; Xinsheng YAO

Xiaojun SONG; Jianming LV; Zhiqin CAO; Huiyun HUANG; Guodong CHEN; Takayoshi AWAKAWA; Dan HU; Hao GAO; Ikuro ABE; Xinsheng YAO.

Acta Pharmaceutica Sinica B ; (6): 1676-1685, 2021.

Article in English | WPRIM | ID: wpr-888828

ABSTRACT

ABSTRACT

Fusidane-type antibiotics, represented by helvolic acid, fusidic acid and cephalosporin P

Combinational biosynthesis; Fungi; Fusidane-type antibiotics; Tailoring enzymes; Triterpenoids

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Full text: Available Index: WPRIM (Western Pacific) Language: English Journal: Acta Pharmaceutica Sinica B Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: English Journal: Acta Pharmaceutica Sinica B Year: 2021 Type: Article