Coating with flexible DNA network enhanced T-cell activation and tumor killing for adoptive cell therapy

Ziyan ZHANG; Qiaojuan LIU; Jizhou TAN; Xiaoxia ZHAN; Ting LIU; Yuting WANG; Gen LU; Minhao WU; Yuanqing ZHANG

Ziyan ZHANG; Qiaojuan LIU; Jizhou TAN; Xiaoxia ZHAN; Ting LIU; Yuting WANG; Gen LU; Minhao WU; Yuanqing ZHANG.

Acta Pharmaceutica Sinica B ; (6): 1965-1977, 2021.

Article in English | WPRIM | ID: wpr-888845

ABSTRACT

ABSTRACT

Adoptive cell therapy (ACT) is an emerging powerful cancer immunotherapy, which includes a complex process of genetic modification, stimulation and expansion. During these

Adoptive cell therapy; Cell surface engineering; DNA nanostructure; Rolling circle amplification; Selective cytoprotection; T cell; Tetrahedral DNA nanostructure; Tumor-killing

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Full text: Available Index: WPRIM (Western Pacific) Language: English Journal: Acta Pharmaceutica Sinica B Year: 2021 Type: Article