The biology, function, and applications of exosomes in cancer
Acta Pharmaceutica Sinica B
;
(6): 2783-2797, 2021.
Article
in English
| WPRIM
| ID: wpr-888887
ABSTRACT
Exosomes are cell-derived nanovesicles with diameters from 30 to 150 nm, released upon fusion of multivesicular bodies with the cell surface. They can transport nucleic acids, proteins, and lipids for intercellular communication and activate signaling pathways in target cells. In cancers, exosomes may participate in growth and metastasis of tumors by regulating the immune response, blocking the epithelial-mesenchymal transition, and promoting angiogenesis. They are also involved in the development of resistance to chemotherapeutic drugs. Exosomes in liquid biopsies can be used as non-invasive biomarkers for early detection and diagnosis of cancers. Because of their amphipathic structure, exosomes are natural drug delivery vehicles for cancer therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Screening study
Language:
English
Journal:
Acta Pharmaceutica Sinica B
Year:
2021
Type:
Article
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