Simultaneous improvement to solubility and bioavailability of active natural compound isosteviol using cyclodextrin metal-organic frameworks

Xiaojin CHEN; Tao GUO; Kaikai ZHANG; Jiacai CHEN; Caifen WANG; Xiaohong REN; Qin WANG; Yingchao YANG; Chongjing LIU; Wen TAN; Shuangying GUI; Li WU; Jiwen ZHANG

Xiaojin CHEN; Tao GUO; Kaikai ZHANG; Jiacai CHEN; Caifen WANG; Xiaohong REN; Qin WANG; Yingchao YANG; Chongjing LIU; Wen TAN; Shuangying GUI; Li WU; Jiwen ZHANG.

Acta Pharmaceutica Sinica B ; (6): 2914-2923, 2021.

Article in En | WPRIM | ID: wpr-888894

Responsible library: WPRO

ABSTRACT

ABSTRACT

Cyclodextrin metal-organic framework (CD-MOF) as a highly porous supramolecular carrier could be one of the solutions to the insolubility of isosteviol (STV). The solubility of STV was lower than 20.00 ng/mL at pH 1.0 and pH 4.5, whilst its solubility increased to 20,074.30 ng/mL at pH 6.8 and 129.58 ng/mL in water with a significant pH-dependence. The

Key words

Bioavailability; Cyclodextrin metal-organic framework; Drug loading; Isosteviol; Molecular simulation; Nanoclusters; Solubility; Supramolecule

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Full text: 1 Index: WPRIM Language: En Journal: Acta Pharmaceutica Sinica B Year: 2021 Type: Article

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Full text: 1 Index: WPRIM Language: En Journal: Acta Pharmaceutica Sinica B Year: 2021 Type: Article