Insulin-Like Growth Factor 1 Actions in Developing Brain and the Interaction with Wnt Pathway
Annals of Pediatric Endocrinology & Metabolism
;
: 10-15, 2012.
Article
in Korean
| WPRIM
| ID: wpr-89115
ABSTRACT
Insulin like growth factor (IGF)-1 signaling through type 1 IGF receptor (IGF1R) is essential to the normal growth and development of the central nervous system. IGF-1 stimulates proliferation of neural stem cells and neural progenitors. IGF-1 also promotes survival and differentiation of neurons and oligodendrocytes, including neuritic outgrowth, synaptogenesis, and myelin production. The phosphatidylinositol 3 kinase (PI3)-Akt pathway and mitogen-activated protein (MAP) kinase pathway are two predominant mediators of IGF1-IGF1R signaling in neural cells. beta-catenin, a key molecule of the canonical Wnt signaling pathway, is also a downstream target of PI3-Akt-glycogen synthase kinase 3beta (GSK3beta) pathway. IGF-1 signaling through IGF1R interacts with canonical Wnt pathway at the levels of GSK3beta and beta-catenin rather than at the levels of Wnt ligands and Frizzled receptors to promote neural proliferation in developing central nervous system.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phosphotransferases
/
Brain
/
Insulin-Like Growth Factor I
/
Central Nervous System
/
Oligodendroglia
/
Glycogen Synthase Kinase 3
/
Growth and Development
/
Wnt Proteins
/
Beta Catenin
/
Frizzled Receptors
Language:
Korean
Journal:
Annals of Pediatric Endocrinology & Metabolism
Year:
2012
Type:
Article
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