Effect of a Soothing Cooler on Pruritus in Mild Atopic Dermatitis / 대한피부과학회지

ABSTRACT

Background@#Atopic dermatitis (AD) is a chronic inflammatory skin disease that often results in a severely reduced quality of life due to its irritating symptoms. Cooling the skin can be an effective supplement for pruritus in the case of AD, since it can modulate itch sensitivity, which has an antipruritic effect. @*Objective@#The aim of this study was to evaluate the effect of a soothing cooler on relieving pruritus in the case of mild AD. @*Methods@#Thirty patients with mild AD were enrolled in this study. They were advised to use the soothing cooler on their left forearms twice daily for eight weeks. Immediate responses were assessed at baseline, and follow-up was done at weeks 2, 4, and 8 to evaluate long-term responses. The effect of the soothing cooler was evaluated using the visual analogue scale for pruritus, transepidermal water loss, hydration capacitance, and the Investigator’s Global Assessment scale for AD. Safety was monitored through the report of adverse events during the study period. @*Results@#There were immediate and long-term improvements in the visual analogue scale scores of left forearm pruritus (p＜0.05), which were statistically significant. No adverse event was reported during the study period. @*Conclusion@#The results of this study demonstrated the pruritus-relieving effect of the soothing cooler for patients with mild AD.