Chondroid Syringoma: A Clinical and Histopathological Study of 17 Cases / 대한피부과학회지

ABSTRACT

Background@#Chondroid syringoma (CS) is an uncommon benign neoplasm of the head and neck seen in middle-aged to elderly individuals. Histopathologically, chondroid syringoma displays nests of cuboidal epithelial cells embedded in a matrix. It is classified as both a tubular branching lumina type and a small tubular lumina type and may exhibit a wide range of differentiation and metaplastic changes in the epithelial and stromal components. @*Objective@#To investigate the correlation between the clinical and histopathologic features of chondroid syringoma. @*Methods@#We evaluated the electronic medical records, clinical photographs, and histopathological slides of 17 patients diagnosed with chondroid syringoma. @*Results@#CS in the terminal hair skin tended to have larger lesions (p=0.036). Tumors in terminal hair skin demonstrated significantly more follicular differentiation (p=0.044) than those in the vellus hair skin. CS arising on the scalp tended to have more osseous metaplasia compared to those arising on non-scalp areas (p=0.022). @*Conclusion@#This study showed that the clinical and histopathological features of CS can differ depending on its location.