The effect of 6% hydroxyethyl starch (670/0.75) on hemostasis during acute normovolemic hemodilution / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 40-45, 2008.
Article
in Korean
| WPRIM
| ID: wpr-89438
ABSTRACT
BACKGROUND:
Hydroxyethyl starch (HES), a widely used plasma volume expander, has been associated with platelet dysfunction and inhibition of coagulation. Six% HES (Molecular weight 670 kd, molar substitution 0.75) is a plasma volume expander in a physiologically balanced medium of electrolytes, lactate and glucose. The aim of this study is to evaluate the effect of 6% HES (670/0.75) on hemostasis during acute normovolemic hemodilution (ANH).METHODS:
Eighteen healthy adult male patients scheduled for spine surgery were enrolled in this study. Before general anesthesia, patients underwent ANH with 20 ml/kg of 6% HES (670/0.75). Hemoglobin, platelet count, plasma fibrinogen concentration, factor VII activity, prothrombin time (PT), activated partial thromboplastin time (aPTT) and thromboelastography (TEG) were measured before and 120 minutes after the completion of ANH.RESULTS:
Hb, Hct, platelet, plasma fibrinogen concentration and factor VII activity decreased significantly (P < 0.05) after ANH. Compared with pre-ANH values, only maximal amplitude decreased significantly (P = 0.001) among post-ANH thromboelastographic parameters.CONCLUSIONS:
Except maximal amplitude, significant difference were not observed in CI (Coagulation Index) which represents general coagulation state and other thromboelastographic parameters between pre and post ANH. ANH with 20 ml/kg of 6% HES (670/0.75) didn't cause impairment of TEG parameters.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Partial Thromboplastin Time
/
Plasma
/
Plasma Volume
/
Platelet Count
/
Prothrombin Time
/
Spine
/
Thrombelastography
/
Blood Platelets
/
Factor VII
/
Fibrinogen
Limits:
Adult
/
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
2008
Type:
Article
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