Quercetin attenuates the reduction of parvalbumin in middle cerebral artery occlusion animal model / 한국실험동물학회지
Laboratory Animal Research
;
: 74-81, 2021.
Article
in English
| WPRIM
| ID: wpr-894946
ABSTRACT
Background@#Calcium is a critical factor involved in modulation of essential cellular functions. Parvalbumin is a calcium buffering protein that regulates intracellular calcium concentrations. It prevents rises in calcium concentrations and inhibits apoptotic processes during ischemic injury. Quercetin exerts potent antioxidant and anti-apoptotic effects during brain ischemia. We investigated whether quercetin can regulate parvalbumin expression in cerebral ischemia and glutamate toxicity-induced neuronal cell death. Adult male rats were treated with vehicle or quercetin (10 mg/kg) 30 min prior to middle cerebral artery occlusion (MCAO) and cerebral cortical tissues were collected 24 h after MCAO. We used various techniques including Western blot, reverse transcriptionPCR, and immunohistochemical staining to elucidate the changes of parvalbumin expression. @*Results@#Quercetin ameliorated MCAO-induced neurological deficits and behavioral changes. Moreover, quercetin prevented MCAO-induced a decrease in parvalbumin expression. @*Conclusions@#These findings suggest that quercetin exerts a neuroprotective effect through regulation of parvalbumin expression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
English
Journal:
Laboratory Animal Research
Year:
2021
Type:
Article
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