Effects of postoperative parenteral nutrition with different lipid emulsions in patients undergoing major abdominal surgery
Annals of Surgical Treatment and Research
;
: 309-315, 2016.
Article
in English
| WPRIM
| ID: wpr-89525
ABSTRACT
PURPOSE:
This study was designed to investigate the effects of total parenteral nutrition (PN) using different lipid emulsions in patients undergoing major abdominal surgery.METHODS:
Fifty-two patients were randomized to receive soybean oil + medium chain triglycerides (MCT) (group I), soybean oil + olive oil (group II), soybean oil + olive oil + fish oil (group III) as a lipid source. PN was started on postoperative day 1 and patients were maintained on PN for a minimum period of 4 days. Laboratory variables (CRP, prealbumin, transferrin) were measured before surgery and on postoperative days.RESULTS:
Three treatment groups were included in the study. Patients in group I received long chain triglycerides (LCT) + LCT/MCT emulsion (%75 LCT + %25 LCT/MCT); Patients in group II received olive oil based emulsion (80% olive oil + 20% soybean oil, ClinOleic); Patients in group III received fish oil in addition to olive oil based emulsion (%85 ClinOleic + %15 Omegaven; Fresenius Kabi). The following 14 parameters were assessed body weight, CRP, prealbumin, transferrin, tumor necrosis factor-α, interleukin-6, total antioxidant status, thiobarbituric acid reactive substances, oxidized low density lipoprotein-2, complete blood cell, international normalized ratio, D-dimer, activated partially thromboplastin time, prothrombin time. All other parameters showed no differences among the groups.CONCLUSION:
The results of our trial demonstrate a potential beneficial effect of soybean oil/olive oil based lipid emulsions for use in PN regarding inflammatory response and oxidant capacity in the treatment of patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prothrombin Time
/
Soybeans
/
Triglycerides
/
Blood Cells
/
Body Weight
/
Soybean Oil
/
Prealbumin
/
Thromboplastin
/
Transferrin
/
Fish Oils
Type of study:
Controlled clinical trial
Limits:
Humans
Language:
English
Journal:
Annals of Surgical Treatment and Research
Year:
2016
Type:
Article
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