Medullary thyroid carcinoma: a 30-year experience at one institution in Korea
Annals of Surgical Treatment and Research
;
: 278-287, 2016.
Article
in English
| WPRIM
| ID: wpr-89529
ABSTRACT
PURPOSE:
The objective of this study was to review the clinical outcome and prognosis of patients with sporadic and hereditary medullary thyroid cancer (MTC) who were treated at a single tertiary hospital in Korea.METHODS:
We retrospectively reviewed the case files of 85 patients treated from August 1982 to February 2012.RESULTS:
In all, 65 patients (76.5%) had sporadic MTC and 20 patients (23.5%) had hereditary MTC. Patients in the sporadic group were older than in the hereditary group (P < 0.001). However, the hereditary group had more tumor multiplicity (P < 0.001) and bilaterality (P < 0.001). Neither survival rate was significantly different between the sporadic and hereditary groups (P = 0.775 and P = 0.866). By multivariate analysis, distant metastasis was a significant prognostic factor for overall and progression-free survival.CONCLUSION:
In general, patients with MTC have favorable outcomes. Distant metastasis appears to be the strongest predictor of overall and progression-free survival.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Thyroid Gland
/
Thyroid Neoplasms
/
Multivariate Analysis
/
Survival Rate
/
Retrospective Studies
/
Disease-Free Survival
/
Tertiary Care Centers
/
Korea
/
Neoplasm Metastasis
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Annals of Surgical Treatment and Research
Year:
2016
Type:
Article
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