Economic Burden of High-Responding Inhibitors in Patients with Hemophilia A in Taiwan
Yonsei Medical Journal
;
: 358-365, 2013.
Article
in English
| WPRIM
| ID: wpr-89575
ABSTRACT
PURPOSE:
Hemophilia A (HA) is the most common X-linked inherited bleeding disorder. In some patients with HA, particularly those with severe HA, replacement therapy results in the production of high-responding clotting factor VIII inhibitors. The economic burden of this complication is the highest reported for a chronic disease. Our aim was to investigate the direct medical expenditure burden of high-responding inhibitors in patients with HA. MATERIALS ANDMETHODS:
A retrospective study was conducted using the National Health Insurance Research Database, utilizing data covering the period of 2004-2007.RESULTS:
In total, 638 males with HA, including 37 patients with high-responding inhibitors were evaluated. Over 99% of the annual median medical expenditure was attributable to the cost of clotting factor concentrates (CFCs) in patients with high-responding inhibitors. The annual median expenditure related to CFCs of the total medical care and outpatient care were US$170611 and US$141982, respectively, and were 4.6- and 4.3-fold higher in these patients during the study period, respectively. In patients with high-responding inhibitors, the median hospitalization expenditure and daily hospitalization cost with or without surgical procedures were 3.0- and 2.4-fold higher, respectively, and 4.3 and 5.6-fold higher, respectively.CONCLUSION:
Our data reveal higher medical expenditures burden for patients with HA and high-responding inhibitors in Taiwan. Future research is encouraged to evaluate the impact of this burden on patient quality of life.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Quality of Life
/
Taiwan
/
Drug Resistance
/
Factor VIII
/
Retrospective Studies
/
Cost of Illness
/
Hemophilia A
/
Hospitalization
Type of study:
Health economic evaluation
/
Observational study
Limits:
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Yonsei Medical Journal
Year:
2013
Type:
Article
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