Management of Diabetes in Coronavirus Disease 2019: Prognosis and Practical Issues / 임상당뇨병

ABSTRACT

The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was declared a global pandemic by the World Health Organization on March 11, 2020. COVID-19 pandemic emphasizes the importance of understanding the pathophysiology which can potentially influence the treatment choices of people with chronic disease such as type 2 diabetes.The reasons for worse prognosis with COVID-19 in people with diabetes include age, sex, ethnicity, comorbidities such as hypertension, cardiovascular disease, obesity and a proinflammatory status.Medications for glucose-lowering and antihypertensive agents should be carefully assessed which can modulate the risk or may have potential interactions with SARS-CoV-2. It is also important to note that SARS-CoV-2 may exacerbate glucose metabolism through direct beta-cell damage, leading to acute hyperglycemic complications and potential new onset diabetes.