Protective Effects of KH-204 in the Bladder of Androgen-Deprived Rats
The World Journal of Men's Health
;
: 73-80, 2015.
Article
in English
| WPRIM
| ID: wpr-89593
ABSTRACT
PURPOSE:
We investigated the protective effects of the herbal formulation KH-204 in the bladder of androgen-deprived rats. MATERIALS ANDMETHODS:
Male rats aged eight weeks were randomly divided into four groups, containing eight rats each sham operation only (normal control group), androgen-deprived only (androgen-deprived control group), and androgen-deprived followed by treatment with 200 mg/kg or 400 mg/kg of KH-204. After 0.5 mg/kg of leuprorelin was subcutaneously injected in the androgen-deprived groups, the oral administration of either distilled water in the two control groups or KH-204 in the treatment group was continued for four weeks. Serum testosterone levels, RhoGEF levels, nitric oxide (NO)-cyclic guanosine monophosphate (cGMP)-related parameters, oxidative stress, and histologic changes were evaluated after treatment.RESULTS:
Treatment with the herbal formulation KH-204 (1) increased serum testosterone levels; (2) restored the expression of RhoGEFs, endothelial NO synthase, and neuronal NO synthase; (3) increased the expression of superoxide dismutase; and (4) decreased bladder fibrosis.CONCLUSIONS:
Our results suggest that the positive effects of KH-204 on the urinary bladder may be attributed to its antioxidant effects or to an elevation in NO-cGMP activity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Superoxide Dismutase
/
Testosterone
/
Urinary Bladder
/
Fibrosis
/
Water
/
Administration, Oral
/
Leuprolide
/
Guanosine Monophosphate
/
Oxidative Stress
/
Nitric Oxide Synthase
Limits:
Animals
/
Humans
/
Male
Language:
English
Journal:
The World Journal of Men's Health
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS