Metabolic Abnormalities in Patients with Mitochondrial Myopathy Evaluated by In Vivo 31P Magnetic Resonance Spectroscopy
Journal of the Korean Society of Magnetic Resonance in Medicine
;
: 89-95, 1998.
Article
in English
| WPRIM
| ID: wpr-89736
ABSTRACT
PURPOSE:
To investigate the phosphorus metabolic abnormalities in skeletal muscle of patients with mitochondrial myopathy using in vivo 31P magnetic resonance spectroscopy(MRS). MATERIAL ANDMETHODS:
Patients with mitochondrial myopathy(N=10) and normal control subjects (N=10) participated. All in vivo 31P MRS examinations were performed on 1.5T whole-body MRI/MRS system by using an image selected in vivo spectroscopy (ISIS) pulse sequence that provided a 4 X 4 X 4 cm3 volume of interest (VOI) in the right thigh muscle tissue. Peak areas for each phophorus methabolite were measured using a Marquart algorithm.RESULTS:
The specific features in patients with mitochondrial myopathy were a significant increase of Pi/PCr ratio (p=0.003) and a significant decrease of ATP/PCr ratio (p=0.004) as compared with normal controls. In particular, the beta-ATP/PCr ratio between controls and patients with mitochondrial myopathy was predominantly altered.CONCLUSIONS:
In vivo 31P MRS may be a useful modality in the clinical evaluation of patients with mitochondrial myopathy based on ATP/PCr and Pi/PCr ratios in skeletal muscle tissue and provides a valuable information in further understanding disorders of muscle metabolism.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phosphorus
/
Spectrum Analysis
/
Thigh
/
Magnetic Resonance Spectroscopy
/
Mitochondrial Myopathies
/
Muscle, Skeletal
/
Metabolism
Limits:
Humans
Language:
English
Journal:
Journal of the Korean Society of Magnetic Resonance in Medicine
Year:
1998
Type:
Article
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