Application of Proteomics and Protein Chip Analysis in the Diagnosis of Neurodegenerative Disorders
Journal of the Korean Neurological Association
; : 584-599, 2003.
Article
in Ko
| WPRIM
| ID: wpr-89758
Responsible library:
WPRO
ABSTRACT
As we face an increase of the adult population suffering from dementia, a typical senile disorder, it is imperative to develop appropriate tools for early detection and differential diagnosis of dementia. Recently, proteomics techniques have been proposed to be used for diagnosis of neurodegenerative disorders by identifying numerous biological markers that are known to increase or decrease in the cerebrospinal fluid or serum of dementic patients. Protein chip analysis, one of the most important techniques of proteomics, is suggested to be useful for examining various modifications of proteins as the high throughput screening method using small volumes of precious samples in a short period. We describe here a list of biological markers, such as A beta, APP, tau, ubiquitin, S100B, soluble IL-6 receptor, beta 2 micoglobulin and prostaglandin E2, proposing that these molecules can be used as biochemical markers of dementia. Therefore, we suggest that the proteomic approaches to analyze the amount and modifications of these proteins might be powerful tools for early detection and differential diagnosis of various neurodegenerative disorders as well as assessment of disease progress.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Biomarkers
/
Dinoprostone
/
Cerebrospinal Fluid
/
Mass Screening
/
Neurodegenerative Diseases
/
Receptors, Interleukin-6
/
Ubiquitin
/
Dementia
/
Protein Array Analysis
/
Proteomics
Type of study:
Diagnostic_studies
/
Screening_studies
Limits:
Adult
/
Humans
Language:
Ko
Journal:
Journal of the Korean Neurological Association
Year:
2003
Type:
Article