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Effect of Human or Mouse IL-7 on the Homeostasis of Porcine T Lymphocytes
Immune Network ; : e24-2021.
Article in English | WPRIM | ID: wpr-898576
Responsible library: WPRO
ABSTRACT
Due to the inconsistent fluctuation of blood supply for transfusion, much attention has been paid to the development of artificial blood using other animals. Although mini-pigs are candidate animals, contamination of mini-pig T cells in artificial blood may cause a major safety concern. Therefore, it is important to analyze the cross-reactivity of IL-7, the major survival factor for T lymphocytes, between human, mouse, and mini-pig. Thus, we compared the protein sequences of IL-7 and found that porcine IL-7 was evolutionarily different from human IL-7. We also observed that when porcine T cells were cultured with either human or mouse IL-7, these cells did not increase the survival or proliferation compared to negative controls. These results suggest that porcine T cells do not recognize human or mouse IL-7 as their survival factor.
Full text: Available Index: WPRIM (Western Pacific) Language: English Journal: Immune Network Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: English Journal: Immune Network Year: 2021 Type: Article