Grading of Superficial Bladder Cancer by Mitotic Indices / 대한비뇨기과학회지

ABSTRACT

The relationship between the prognostic factors and recurrence was investigated in the followup study of patients with 51 superficial (stage Ta to T1) transitional cell bladder carcinomas for more than 3 years. WHO grade, modified Bergkvist grade and number of tumor were related to mitotic indices( p <0.05), but size of tumor was related to MAI only(p<0.05) In univariate analysis of prognostic factors, mitotic indices, number of tumor and posterior wall involvement were related to 3-year recurrence(p < 0.05). In multivariate analysis of prognostic factors, which were significantly related in univariate analysis, VCM and posterior wall involvement were related to 3-year recurrence and their hazard ratios were 9.33 times and 6.16 times In recurrence-free survival curve of prognostic factors, mitotic indices, number of tumor and posterior wall involvement were related (p <0.05). In classifying WHO grade 2 according to modified Bergkvist grade and mitotic indices, they were related to recurrence (p <0.05). The results show that superficial transitional cell bladder carcinomas can be efficiently categorized into prognostic groups by mitotic indices and the results provide a new classification system for superficial transitional cell bladder carcinomas.