Antitumor effects of octyl gallate on hypopharyngeal carcinoma cells
International Journal of Oral Biology
;
: 218-224, 2020.
Article
in English
| WPRIM
| ID: wpr-898687
ABSTRACT
The antitumor effects of octyl gallate (OG) were investigated on FaDu human hypopharyngeal squamous carcinoma cells. At various concentrations, OG inhibited the proliferation of FaDu cells by suppressing cell cycle regulators and induced apoptosis by activating caspase 3 and its downstream poly (ADP-ribose) polymerase, thereby damaging DNA. Immunoblotting demonstrated that OG significantly suppressed the expression of integrin family proteins (integrin α4, αv, β3, β4), hindering cell adhesion. The reduced expression of integrins subsequently mediated the mitogen- activated protein kinase signaling pathway to stimulate the activation of extracellular signal-regulated kinases and c-jun N-terminal kinases, leading to apoptosis. Thus, OG demonstrated antitumor activity on hypopharyngeal squamous carcinoma cells by suppressing cell proliferation and inducing apoptosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
English
Journal:
International Journal of Oral Biology
Year:
2020
Type:
Article
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