Longitudinal Observation of Early-Onset Alzheimer’s Disease Dementia with Positive CSF Biomarkers/Negative Amyloid-β Positron-Emission Tomography
Journal of the Korean Neurological Association
;
: 214-218, 2021.
Article
in Korean
| WPRIM
| ID: wpr-900896
ABSTRACT
We report a 61-year-old woman with clinical course for Alzheimer’s disease (AD) dementia and discordant amyloid-β positron-emission tomography (PET) and cerebrospinal fluid biomarkers. Brain magnetic resonance imaging revealed remarkable atrophy in the hippocampus. However, repeated delayed 18F-flutemetamol brain amyloid PET images with 1 year-interval revealed no amyloid deposition, whereas her CSF revealed low Aβ42, high total tau and p-tau181. This discordant amyloid-β PET and CSF biomarkers in this early-onset AD dementia might be associated with her low resilience or mixed pathology.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Korean
Journal:
Journal of the Korean Neurological Association
Year:
2021
Type:
Article
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