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Effectiveness and Safety of Two Different Formulations of Oral Propranolol Treatment for 375 Cases of Infantile Hemangioma: A Korean Single-center Experience / 대한피부과학회지
Korean Journal of Dermatology ; : 196-205, 2021.
Article in English | WPRIM | ID: wpr-901997
ABSTRACT
Background@#Oral propranolol has recently been introduced as a successful treatment for infantile hemangioma (IH).Though, there are limited reports on this treatment including large number of Korean patients with IH covering a long-term powder and solution formulation period. @*Objective@#We investigated the effectiveness and side effects of two different formulations of oral propranolol treatment in patients with IH at a Korean tertiary university hospital. @*Methods@#From June 2011 to October 2019, 375 patients were treated with powder- or solution-type oral propranolol starting at 1 mg/kg/day and increasing up to 3 mg/kg/day. Drug effectiveness was evaluated on four scales through sequential photographs by two dermatologists. Side effects were recorded on a medical chart. @*Results@#Overall, the mean improvement scale was 2.61±0.73 at 3 months after treatment initiation. The scale was higher for solution-type than for powder-type oral propranolol at the 3-month follow-up (2.71±0.79 vs. 2.54±0.67, p<0.05). The patients’ mean duration of treatment was 8.56±5.85 months, which was shorter for solution-type than for powder-type oral propranolol (6.0 vs. 10.69 months, p<0.05). Among the total number of patients, 22 reported mild side effects, including loose stools and noticeable sleep disturbance, and few serious side effects such as grunting, while two patients required medical intervention. @*Conclusion@#The patients in our study were effectively treated for IH with oral propranolol without significant side effects and had a shorter treatment duration with solution-type oral propranolol than with powder-type oral propranolol.
Full text: Available Index: WPRIM (Western Pacific) Language: English Journal: Korean Journal of Dermatology Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: English Journal: Korean Journal of Dermatology Year: 2021 Type: Article