Short-, Intermediate-, and Long-Term Changes in Basophil Reactivity Induced by Venom Immunotherapy
Allergy, Asthma & Immunology Research
;
: 412-420, 2016.
Article
in English
| WPRIM
| ID: wpr-90244
ABSTRACT
PURPOSE:
The basophil activation test (BAT) has been used to monitor venom immunotherapy (VIT) due to its high specificity. A previous study has reported a good correlation between a significant decrease in basophil activation during 5 years of VIT and clinical protection assessed by sting challenge. The following prospective study was performed to examine changes in basophil reactivity over a complete VIT period of 5 years.METHODS:
BAT in a dose-response curve was studied prospectively in 10 hymenoptera venom-allergic patients over 5 years of VIT. BAT was performed at the time of diagnosis, 1 month after finishing the VIT build-up phase, and 3, 6, 12, 24, and 60 months after beginning treatment. The repeated measures ANOVA was applied to evaluate basophil activation changes throughout VIT. A cross-sectional study was also performed in 6 patients who received treatment for more than 3 years, and in another 12 patients who followed immunotherapy for at least 5 years.RESULTS:
An early activation decrease was observed during the first 3 months of treatment, compared to pre-treatment values. This activation decrease was not maintained 6 to 18 months after treatment, but was observed again after 2 years of treatment, and maintained until the completion of the 5-year immunotherapy period. In cross-sectional analysis, the 6 patients who received treatment for 3 years, and 9 of the 12 patients who received treatment for 5 years, had negative BAT results. Three patients in this last group had positive BAT results and 2 patients had systemic reactions after field stings.CONCLUSIONS:
BAT appears to be an optimal non-invasive test for close monitoring of VIT.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Venoms
/
Basophils
/
Bites and Stings
/
Cross-Sectional Studies
/
Prospective Studies
/
Sensitivity and Specificity
/
Diagnosis
/
Hymenoptera
/
Immunotherapy
Type of study:
Diagnostic study
/
Observational study
/
Prevalence study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Allergy, Asthma & Immunology Research
Year:
2016
Type:
Article
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