Assessment of the correlation between various risk factors and orofacial cleft disorder spectrum: a retrospective case-control study / 대한악안면성형재건외과학회지
Maxillofacial Plastic and Reconstructive Surgery
;
: 26-2020.
Article
in English
| WPRIM
| ID: wpr-902698
ABSTRACT
Background@#Orofacial clefts (OFCs) comprise a wide range of malformations, including cleft lip, cleft palate, and cleft lip with cleft palate, which can vary in terms of etiology, severity, and disease burden. @*Objective@#(s)This study aimed to evaluate the correlation between various risk factors and orofacial cleft disorder spectrum in newborns.Study designA total of 323 cases and 400 controls were enrolled in this study and evaluated in terms of the maternal history of abortion or miscarriage, child’s sex, maternal and paternal age, maternal history of systemic disease, history of medication therapy during pregnancy, birth order, consanguineous marriage, and complications during pregnancy. @*Results@#Analysis of the results suggested that consanguineous marriage, a maternal history of abortion/miscarriage, and complications during pregnancy could potentially increase the risk of OFCs in children (P 0.05). @*Conclusion@#(s)Multiple cofactors may simultaneously contribute to the formation of such abnormalities; therefore, a comprehensive, multidisciplinary care program is necessary to ensure a successful pregnancy period and the birth of a healthy newborn.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
/
Observational study
/
Risk factors
Language:
English
Journal:
Maxillofacial Plastic and Reconstructive Surgery
Year:
2020
Type:
Article
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