Proton-pump Inhibitors and the Risk of Dementia: A Systematic Review and Meta-analysis
The Korean Journal of Helicobacter and Upper Gastrointestinal Research
; : 135-143, 2021.
Article
in En
| WPRIM
| ID: wpr-903621
Responsible library:
WPRO
ABSTRACT
Background/Aims@#Proton pump inhibitors (PPIs) are widely used to treat several acid-related gastrointestinal disorders. This study aimed to investigate the risk of dementia in patients taking PPIs. @*Materials and Methods@#A systematic review was conducted to evaluate the correlation between PPIs and dementia. The methodological quality of the included studies was evaluated using the Risk of Bias Assessment tool for non-randomized studies. Publication bias was assessed. @*Results@#A total of 12 nested, case-control, and cohort studies were identified and analyzed. We obtained hazard ratios (HRs) from five studies and performed a meta-analysis. The meta-analysis of four cohort studies and one nested case-control study showed no association between PPIs and dementia (HR, 1.165; 95% CI, 0.912~1.488; P=0.222). Sensitivity analysis revealed consistent results. No publication bias was detected. @*Conclusions@#This systematic review and meta-analysis revealed no statistically significant association between the use of PPIs and dementia.
Full text:
1
Index:
WPRIM
Type of study:
Clinical_trials
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Etiology_studies
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Observational_studies
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Risk_factors_studies
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Systematic_reviews
Language:
En
Journal:
The Korean Journal of Helicobacter and Upper Gastrointestinal Research
Year:
2021
Type:
Article