Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo
The Korean Journal of Parasitology
;
: 297-301, 2021.
Article
in English
| WPRIM
| ID: wpr-903879
ABSTRACT
Toxoplasma gondii infection is widespread worldwide, not only posing a serious threat to human food safety and animal husbandry, but also endangering human health. The selectivity index was employed to measure anti-T. gondii activity. Hederagenin (HE) exhibited potent anti-T. gondii activity and low cytotoxicity. For this reason, HE was selected for in vivo experiments. HE showed 64.8%±13.1% inhibition for peritoneal tachyzoites in mice, higher than spiramycin 56.8%±6.0%. Biochemical parameters such as alanine aminotransferase, aspartate aminotransferase, glutathione, and malondialdehyde, illustrated that HE was a good inhibitor of T. gondii in vivo. This compound was also effective in relieving T. gondii-induced liver damage. Collectively, it was demonstrated that HE had potential as an anti-T. gondii agent.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
English
Journal:
The Korean Journal of Parasitology
Year:
2021
Type:
Article
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