Incidence and Clinical Outcomes of Febrile Neutropenia in Adult Cancer Patients with Chemotherapy Using Korean Nationwide Health Insurance Database
Yonsei Medical Journal
;
: 479-486, 2021.
Article
in English
| WPRIM
| ID: wpr-904246
ABSTRACT
Purpose@#The aim of this study was to evaluate the episodes of febrile neutropenia (FN) in patients with gastric cancer (GC), colorectal cancer (CRC), lung cancer (LC), and breast cancer (BC); and to identify the incidence and trends of admission rates, as well as factors affecting mortality. @*Materials and Methods@#Using nationwide claims data, all new admissions to hospitals for FN were selected. We evaluated the incidence of FN and mortality-related clinical factors in adult cancer patients who received cytotoxic chemotherapy from January 2004 to December 2013. @*Results@#While the incidence of FN increased, the length of hospitalization decreased in Korea. The incidence of FN was 19.8% in LC patients, 15.5% in GC patients, 13.3% in BC patients, and 9.5% in CRC patients. The overall in-hospital mortality of FN was 12.9% and showed a decreasing trend. Admission rates to intensive care units and in-hospital mortality were the highest for lung cancer (15.2% and 19.3%, respectively). Age and sepsis syndrome were risk factors for in-hospital mortality for all cancer types. @*Conclusion@#Careful observation and active prophylaxis should be considered for patients at high risk of FN.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Incidence study
/
Prognostic study
/
Risk factors
Language:
English
Journal:
Yonsei Medical Journal
Year:
2021
Type:
Article
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