Effect of selective laser trabeculoplasty on primary open angle glaucoma in different stages / 国际眼科杂志(Guoji Yanke Zazhi)

ABSTRACT

@#AIM: To assess and compare the effectiveness of selective laser trabeculoplasty(SLT)in preventing primary open angle glaucoma(POAG)with various stages.<p>METHODS: Fifty-one eyes of 27 patients 51 eye with POAG were included in this retrospective study. All the cases were divided into three groups depending on the mean deviation(MD) the early stage group(MD>-6dB, 15 eyes), middle stage group(-12dB≤MD≤-6dB, 15 eyes)and late stage group(MD<-12dB, 21 eyes). All subjects underwent SLT on 360° of the angle between July 2018 to March 2020. The laser parameters of a 532nm, Q-switched, frequency-doubled Nd YAG laser, with 3ns pulse time, 400μm spot diameter were set to selectively target pigmented trabecular meshwork cells without visible damage to the adjacent non-pigmented tissue. Intraocular pressure(IOP)reduction was observed at 1h, 1d, 1, 3, 6 and 12mo after the laser procedure. Meanwhile, the ratio of the IOP reduction, visual field index(VFI), MD, medication, adverse reactions and efficiency were assessed as well.<p>RESULTS: Within the 12mo post-SLT, there were no statistically significant differences for the IOP and IOP decline rate between each group(all <i>P</i>>0.05). There were significant differences in VFI and MD among early, middle and late groups(<i>P</i><0.001), within the 12mo post-SLT, no statistically significant differences were detected for the decline of VFI and MD in each group. In terms of the early stage group, the effective rates of SLT at 1, 3, 6 and 12mo after treatment were 100%, 93%, 87%, 67%, respectively. For the middle stage group and late stage group, the effective rates were 87%, 80%, 93%, 60%, and 67%, 71%, 62%, 19%, respectively. <p>CONCLUSION: SLT was an effective treatment for POAG patients in various stages, while the effective rate decreased with time.