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Conventional Cisplatin-Based Combination Chemotherapy Is Effective in the Treatment of Metastatic Spermatocytic Seminoma with Extensive Rhabdomyosarcomatous Transformation / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment ; : 931-936, 2015.
Article in English | WPRIM | ID: wpr-90545
ABSTRACT
A 52-year-old man was presented with a huge left testicular mass and palpable cervical lymphadenopathy with retroperitoneal lymph node enlargement on an abdominal computed tomography. A left radical orchiectomy and an ultrasound-guided neck node biopsy were performed. A pathological examination revealed spermatocytic seminoma with extensive rhabdomyosarcomatous transformation, a condition known to be highly resistant to platinum-based chemotherapy. The patient received four cycles of etoposide, ifosfamide and cisplatin (VIP) chemotherapy. A repeat computed tomography revealed a substantial regression consistent with a partial response. Retroperitoneal lymph node dissection was attempted, which revealed rhabdomyosarcoma; however, complete microscopic resection was not achieved. After surgery, the residual abdominal lymph node progressed and salvage paclitaxel, ifosfamide and cisplatin (TIP) chemotherapy was employed, which again achieved a partial response. Here, we present a first case report of a spermatocytic seminoma with extensive rhabdomyosarcomatous transformation and multiple metastatic lymphadenopathies that showed a favorable response to platinum-based systemic chemotherapy.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Radiotherapy / Rhabdomyosarcoma / Biopsy / Orchiectomy / Cisplatin / Paclitaxel / Seminoma / Drug Therapy / Drug Therapy, Combination / Etoposide Limits: Humans Language: English Journal: Cancer Research and Treatment Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Radiotherapy / Rhabdomyosarcoma / Biopsy / Orchiectomy / Cisplatin / Paclitaxel / Seminoma / Drug Therapy / Drug Therapy, Combination / Etoposide Limits: Humans Language: English Journal: Cancer Research and Treatment Year: 2015 Type: Article