Application of Thrombelastography in Prognosis of Cerebral Infarction / 中国康复理论与实践

ABSTRACT

Objective:To explore the value of thrombelastography in long-term prognosis for patients with cerebral infarction. Methods:From January, 2015 to July, 2017, 255 patients with cerebral infarction hospitalized were selected. Thrombelastography and routine coagulation test (four coagulation and platelets) were tested after patients' admission. And thrombelastographic test was performed again 3 months after discharge. The patients were followed up for a year by outpatient visits or telephone contact. According to whether cerebral infarction recurred, they were divided into unfavorable prognosis group (n = 51) and favorable prognosis group (n = 204), and the difference of thrombelastography and routine coagulation test were compared between the two groups. Results:There was no statistically significant difference in total cholesterol, triglyceride, low density lipoprotein cholesterol, diabetes, hypertension, smoking, scores of National Institutes of Health Stroke Scale, and administration of antiplatelet drugs between the two groups (P > 0.05); There was no statistically significant difference in thrombin time, prothrombin time, activated partial thromboplastin time, fibrinogen, and platelet in routine coagulation test between the two groups (P > 0.05). Compared to the favorable prognosis group at admission, reaction time and kinetics time of thrombelastographic test shortened significantly, while rate of clot strengthening and maximum amplitude increased significantly in the unfavorable prognosis group (P < 0.05); three months after discharge, only maximum amplitude increased significantly (P < 0.05) while there was no significant difference in reaction time, kinetics time and rate of clot strengthening in the unfavorable prognosis group (P > 0.05). Conclusion:Abnormal parameters of thrombelastographic test may indicate hypercoagulability in blood in the patients with cerebral infarction which predicts unfavorablein long-term outcome.