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Prognostic Significance of Defining L-Cell Type on the Biologic Behavior of Rectal Neuroendocrine Tumors in Relation with Pathological Parameters / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment ; : 813-822, 2015.
Article in English | WPRIM | ID: wpr-90558
ABSTRACT

PURPOSE:

In 2010, the World Health Organization categorized L-cell type neuroendocrine tumors (NETs) as tumors of uncertain malignancy, while all others were classified as malignant. However, the diagnostic necessity of L-cell immunophenotyping is unclear, as are tumor stage and grade that may guide diagnosis and management. To clarify the predictive markers of rectal neuroendocrine neoplasms (NENs), 5- and 10-year overall survival (OS) was analyzed by pathological parameters including L-cell phenotype. MATERIALS AND

METHODS:

A total of 2,385 rectal NENs were analyzed from our previous multicenter study and a subset of 170 rectal NENs was immunophenotyped.

RESULTS:

In univariate survival analysis, tumor grade (p 10, is useful in defining L-Cell type. In this study, an L-cell immunophenotype was found in 83.5% of all rectal NENs and most, but not all L-cell type tumors were NET G1, small (< 10 mm) and confined to the mucosa/submucosa.

CONCLUSION:

From these results, the biological behavior of rectal NENs does not appear to be determined by L-cell type alone but instead by a combination of pathological parameters.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Phenotype / Prognosis / Rectal Neoplasms / World Health Organization / Glucagon / Immunohistochemistry / International Classification of Diseases / Multivariate Analysis / Immunophenotyping / Neuroendocrine Tumors Type of study: Controlled clinical trial / Diagnostic study / Prognostic study Language: English Journal: Cancer Research and Treatment Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phenotype / Prognosis / Rectal Neoplasms / World Health Organization / Glucagon / Immunohistochemistry / International Classification of Diseases / Multivariate Analysis / Immunophenotyping / Neuroendocrine Tumors Type of study: Controlled clinical trial / Diagnostic study / Prognostic study Language: English Journal: Cancer Research and Treatment Year: 2015 Type: Article