Prognostic Significance of Defining L-Cell Type on the Biologic Behavior of Rectal Neuroendocrine Tumors in Relation with Pathological Parameters / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 813-822, 2015.
Article
in English
| WPRIM
| ID: wpr-90558
ABSTRACT
PURPOSE:
In 2010, the World Health Organization categorized L-cell type neuroendocrine tumors (NETs) as tumors of uncertain malignancy, while all others were classified as malignant. However, the diagnostic necessity of L-cell immunophenotyping is unclear, as are tumor stage and grade that may guide diagnosis and management. To clarify the predictive markers of rectal neuroendocrine neoplasms (NENs), 5- and 10-year overall survival (OS) was analyzed by pathological parameters including L-cell phenotype. MATERIALS ANDMETHODS:
A total of 2,385 rectal NENs were analyzed from our previous multicenter study and a subset of 170 rectal NENs was immunophenotyped.RESULTS:
In univariate survival analysis, tumor grade (p 10, is useful in defining L-Cell type. In this study, an L-cell immunophenotype was found in 83.5% of all rectal NENs and most, but not all L-cell type tumors were NET G1, small (< 10 mm) and confined to the mucosa/submucosa.CONCLUSION:
From these results, the biological behavior of rectal NENs does not appear to be determined by L-cell type alone but instead by a combination of pathological parameters.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Prognosis
/
Rectal Neoplasms
/
World Health Organization
/
Glucagon
/
Immunohistochemistry
/
International Classification of Diseases
/
Multivariate Analysis
/
Immunophenotyping
/
Neuroendocrine Tumors
Type of study:
Controlled clinical trial
/
Diagnostic study
/
Prognostic study
Language:
English
Journal:
Cancer Research and Treatment
Year:
2015
Type:
Article
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