Association between Ser9Gly Polymorphism of DRD3 Gene and Depression in Parkinson's Disease / 中国康复理论与实践
Chinese Journal of Rehabilitation Theory and Practice
;
(12): 553-556, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-905591
ABSTRACT
Objectives:
To explore the relationship between the dopamine D3 receptor (DRD3) polymorphism on Ser9Gly and depression in Parkinson's disease (PD).Methods:
From June, 2016 to June, 2018, 312 Chinese patients with PD were divided into depression group (n = 132) and non-depression group (n = 180) according to scores of Hamilton Depression Scale. A total of 252 age- and gender-matched healthy subjects were recruited as control group. Their blood samples were collected. Genotyping of Ser9Gly polymorphism was carried out using polymerase chain reaction-restriction fragment length polymorphism.Results:
No statistical difference was identified in Ser9Gly polymorphism among three groups in both gene types and allel (χ2 = 3.095, χ2 = 2.627, P > 0.05).Conclusion:
Ser9Gly polymorphism in DRD3 gene may not be a susceptible factor for depression in PD in China.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Rehabilitation Theory and Practice
Year:
2019
Type:
Article
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