Clinical Efficacy of Qinghao Fuzheng Jiedu Decoction in Treatment of Systemic Lupus Erythematous / 中国实验方剂学杂志
Chinese Journal of Experimental Traditional Medical Formulae
;
(24): 138-143, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-905967
ABSTRACT
Objective:
To study the clinical effect of Qinghao Fuzheng Jiedu decoction on systemic lupus erythematous (SLE).Method:
A total of 109 SLE patients admitted to the Rheumatology and Immunology Department of Wuhan No. 1 Hospital from December 2019 to October 2020 were selected and divided into an observation group (55 cases) and a control group (54 cases) using the random number table. Two cases in the observation group dropped out, leaving a total sample of 53, and one case in the control group dropped out, with 53 cases finally included. Patients in the control group were treated with prednisone tablet and azathioprine. On this basis, those in the observation group further received Qinghao Fuzheng Jiedu decoction. The clinical efficacy, traditional Chinese medicine (TCM) syndrome score, TCM syndrome efficacy, immunoglobulin (Ig) G, IgA, IgM, and complements C3 and C4 of the two groups were compared. The conversion of positive antinuclear antibody (ANA) and anti-double-stranded deoxyribonucleic acid antibody (DS-DNA) titers to negative in two groups after treatment was analyzed.Result:
The total clinical efficacy rate of the observation group was significantly higher than that of control group (92.45% vs 73.58%,<italic>χ<sup>2</sup></italic>=6.692,<italic>P</italic><0.05). Before treatment, there were no significant differences in IgG, IgA, IgM, complements C3 and C4, and serum ANA and ds-DNA titers between two groups. After treatment, the levels of IgG, IgA, and IgM and serum ANA and ds-DNA titers in both groups obviously declined, whereas the levels of complements C3 and C4 rose (<italic>P</italic><0.05). Besides, the levels of IgG, IgA, and IgM and serum ANA and ds-DNA titers in the observation group were lower than those in the control group, while the levels of complements C3 and C4 were higher (<italic>P</italic><0.05). The negative rates of ANA and ds-DNA in observation group were significantly higher than those in control group (<italic>χ<sup>2</sup></italic>=8.040,<italic>P</italic><0.05). TCM syndrome scores were decreased in both groups after treatment (<italic>P</italic><0.05), and the score in observation group was lower than that in control group (<italic>P</italic><0.05). In terms of TCM syndrome efficacy, the total effective rate of observation group was significantly increased as compared with that of the control group (94.34% vs 50.94%,<italic>χ<sup>2</sup></italic>=25.112,<italic>P</italic><0.05).Conclusion:
Qinghao Fuzheng Jiedu decoction is effective in treating SLE and has a certain clinical application value.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Experimental Traditional Medical Formulae
Year:
2021
Type:
Article
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