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Research Progress on Heat-clearing Chinese Herbal Compounds Against Diabetes Based on Regulating Intestinal Flora / 中国实验方剂学杂志
Chinese Journal of Experimental Traditional Medical Formulae ; (24): 238-244, 2021.
Article in Chinese | WPRIM | ID: wpr-906261
ABSTRACT
Diabetes has become one of the fastest growing public health issues in the world. Its pathological mechanism is complex and affected by multiple factors. There are trillions of microbes in the human intestine, which are roughly divided into three types: probiotics, neutral bacteria, and pathogenic bacteria. They are in a dynamic balance and constitute a complex intestinal micro-ecosystem. The balance and homeostasis of the intestinal micro-ecosystem are essential to maintain the stability of the body's environment and human health. With the rapid development of high-throughput sequencing technology, imbalanced intestinal flora distribution has been proven to be an important factor in promoting the development of insulin resistance (IR), thus increasing the risk of diabetes. In recent years, the regulation of intestinal flora has become a new approach and new target for the prevention and treatment of diabetes and its complications. The application of traditional Chinese medicine (TCM) in treatment of metabolic diseases such as diabetes and obesity has a long history. TCM has its unique characteristics and advantages, however, the unclear mechanism of action has limited its modernization and industrialization. The harmonious symbiosis between the intestinal flora and the host is consistent with the TCM theory of "harmony between human and nature". The effect of TCM on the intestinal microflora has gradually become a hot topic in medical research today. One study believes that diabetes originates from "intestinal fever". At present, some relevant experimental researches and clinical research literatures have shown that some heat-clearing Chinese herbal compounds have a certain regulating effect on imbalanced intestinal flora. Therefore, the relationship between intestinal flora and diabetes was explored, and the mechanism of heat-clearing Chinese herbal compounds (Da Chaihutang, Gegen Qinliantang, Huanglian Jiedutang, and Wumeiwan) in preventing and treating heat syndrome of diabetes through regulation of intestinal flora was analyzed, in order to provide new theoretical basis and research clues for the further development of drugs for treating diabetes.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Experimental Traditional Medical Formulae Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Experimental Traditional Medical Formulae Year: 2021 Type: Article