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Progress in Application of Population Pharmacokinetic and Pharmacodynamic Models in Research on Traditional Chinese Medicine / 中国实验方剂学杂志
Chinese Journal of Experimental Traditional Medical Formulae ; (24): 226-233, 2021.
Article in Chinese | WPRIM | ID: wpr-906321
ABSTRACT
In recent years, the role of quantitative pharmacological models in applicable population of drugs and dose optimization has been widely recognized. In order to improve the efficiency of clinical development and optimize clinical rational drug use, quantitative pharmacological models are being gradually introduced into the research of traditional Chinese medicine (TCM). There are various types of quantitative pharmacological models, among which the following three models are commonly used:①Population pharmacokinetic (PPK) model, which is mainly used to explore the pharmacokinetic characteristics in different populations.②Pharmacokinetic-pharmacodynamic (PK-PD) model, which is used to reveal the internal relationship among dosetime and efficacy. ③PPK-PD model, which integrates both the characteristics of PPK model and PK-PD model. The paper summarizes the application of the above three models in TCM, and extracts the main ideas and methods of TCM model research, in order to provide reference for clinical research and rational use of TCM.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Chinese Journal of Experimental Traditional Medical Formulae Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Chinese Journal of Experimental Traditional Medical Formulae Year: 2021 Type: Article