Correlates of Metabolic Abnormalities in Bipolar I Disorder at Initiation of Acute Phase Treatment
Psychiatry Investigation
;
: 78-84, 2009.
Article
in English
| WPRIM
| ID: wpr-90642
ABSTRACT
OBJECTIVE:
Treatment of bipolar patients is often complicated by metabolic abnormalities such as obesity, diabetes, and dyslipidemia. We therefore evaluated the prevalence of these abnormalities and their correlates, in bipolar I patients, at the time of commencement of pharmacological treatment for acute mood episodes.METHODS:
The study cohort consisted of 184 bipolar I patients hospitalized for treatment of acute mood episodes. Socio-demographic and clinical variables were noted and metabolic parameters, including body mass index, fasting plasma glucose, fasting total cholesterol, and current treatment(s) for diabetes and/or dyslipidemia were measured before initiating medication(s).RESULTS:
Fifty-six (30.4%) subjects met our criteria for obesity; 80 (43.5%) had hyperglycemia, with 8 (4.3%) receiving anti-diabetic medication; and 38 (20.7%) had hypercholesterolemia, with 2 (1.1%) receiving cholesterol-lowering agents. We found that male sex (chi-square=5.359, p=0.021), depressed or mixed state versus manic state (chi-square=4.302, p=0.038), and duration of illness (t=2.756, p=0.006) were significantly associated with obesity. Older age (t=3.668, p<0.001), later age of disease onset (t=2.271, p=0.024), and lower level of educational attainment (beta=-0.531, p=0.001) were associated with hyperglycemia.CONCLUSION:
Our finding that metabolic abnormalities are prevalent when initiating acute pharmacological treatment in bipolar I patients indicates that these factors should be integrated into treatment plans at the onset of disease management.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Bipolar Disorder
/
Body Mass Index
/
Cholesterol
/
Prevalence
/
Cohort Studies
/
Fasting
/
Disease Management
/
Dyslipidemias
/
Glucose
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prevalence study
/
Risk factors
Limits:
Humans
/
Male
Language:
English
Journal:
Psychiatry Investigation
Year:
2009
Type:
Article
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